AustralieFrV1, Main, Exploration, bibRecord, 009550

Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk

Identifieur interne : 009550 ( Main/Exploration ); précédent : 009549; suivant : 009551

Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk

Auteurs : James D. Mckay [France, Australie] ; Rudolf Kaaks [France, Allemagne] ; Mattias Johansson [Suède] ; Carine Biessy [France] ; Fredik Wiklund [Suède] ; Katarina Baiter [Suède] ; Hans-Olov Adami [Suède] ; Catherine Boillot [France] ; Lydie Gioia-Patricola [France] ; Federico Canzian [France, Allemagne] ; Par Stattin [Suède] ; Henrik Grönberg [Suède]

Source :

Cancer epidemiology, biomarkers & prevention [ 1055-9965 ] ; 2007.

RBID : Pascal:07-0125693

Descripteurs français

Pascal (Inist)
- STH, Haplotype, Etude cas témoin, Cancer prostate, Récepteur hormonal, Gène, Suède, Facteur risque, Epidémiologie, Homme, Cancérologie, Urologie, Néphrologie.
Wicri :
- geographic : Suède.
- topic : Homme.

English descriptors

KwdEn :
- Cancerology, Case control study, Epidemiology, Gene, Haplotype, Hormonal receptor, Human, Nephrology, Prostate cancer, Risk factor, Somatotropin hormone, Sweden, Urology.

Abstract

The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in the GHR gene influences prostate cancer risk. One haplotype in the 3' region of the GHR gene was found associated with prostate cancer risk in elderly men (>65 years old at the time of diagnosis), with heterozygote haplotype carriers having an odds ratio of 1.65 (95% confidence interval, 1.21-2.16; P = 0.0009, P_corrected = 0.03). GHR function has been implicated in the determination of body mass index. Interestingly, the same haplotype associated with risk in the 3' end of the GHR gene was also associated with a decrease in body mass index in controls (P = 0.003, P_corrected = 0.05), possibly indicating some functionality with this haplotype. These results suggest that whereas genetic variation in the GHR gene does not seem to play a major role in prostate cancer etiology, one haplotype in the 3' region may be potentially relevant to cases with later onset of prostate cancer.

Affiliations:

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Le document en format XML

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</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Cancer epidemiology, biomarkers & prevention</title>
<title level="j" type="abbreviated">Cancer epidemiol. biomark. prev.</title>
<idno type="ISSN">1055-9965</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Cancer epidemiology, biomarkers & prevention</title>
<title level="j" type="abbreviated">Cancer epidemiol. biomark. prev.</title>
<idno type="ISSN">1055-9965</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Case control study</term>
<term>Epidemiology</term>
<term>Gene</term>
<term>Haplotype</term>
<term>Hormonal receptor</term>
<term>Human</term>
<term>Nephrology</term>
<term>Prostate cancer</term>
<term>Risk factor</term>
<term>Somatotropin hormone</term>
<term>Sweden</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>STH</term>
<term>Haplotype</term>
<term>Etude cas témoin</term>
<term>Cancer prostate</term>
<term>Récepteur hormonal</term>
<term>Gène</term>
<term>Suède</term>
<term>Facteur risque</term>
<term>Epidémiologie</term>
<term>Homme</term>
<term>Cancérologie</term>
<term>Urologie</term>
<term>Néphrologie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in the GHR gene influences prostate cancer risk. One haplotype in the 3' region of the GHR gene was found associated with prostate cancer risk in elderly men (>65 years old at the time of diagnosis), with heterozygote haplotype carriers having an odds ratio of 1.65 (95% confidence interval, 1.21-2.16; P = 0.0009, P<sub>corrected</sub>
 = 0.03). GHR function has been implicated in the determination of body mass index. Interestingly, the same haplotype associated with risk in the 3' end of the GHR gene was also associated with a decrease in body mass index in controls (P = 0.003, P<sub>corrected</sub>
 = 0.05), possibly indicating some functionality with this haplotype. These results suggest that whereas genetic variation in the GHR gene does not seem to play a major role in prostate cancer etiology, one haplotype in the 3' region may be potentially relevant to cases with later onset of prostate cancer.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Suède</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>Svealand</li>
</region>
<settlement><li>Heidelberg</li>
<li>Stockholm</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name>
</noRegion>
<name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name>
<name sortKey="Boillot, Catherine" sort="Boillot, Catherine" uniqKey="Boillot C" first="Catherine" last="Boillot">Catherine Boillot</name>
<name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<name sortKey="Gioia Patricola, Lydie" sort="Gioia Patricola, Lydie" uniqKey="Gioia Patricola L" first="Lydie" last="Gioia-Patricola">Lydie Gioia-Patricola</name>
<name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
</region>
<name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
</country>
<country name="Suède"><noRegion><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
</noRegion>
<name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name>
<name sortKey="Baiter, Katarina" sort="Baiter, Katarina" uniqKey="Baiter K" first="Katarina" last="Baiter">Katarina Baiter</name>
<name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<name sortKey="Stattin, Par" sort="Stattin, Par" uniqKey="Stattin P" first="Par" last="Stattin">Par Stattin</name>
<name sortKey="Wiklund, Fredik" sort="Wiklund, Fredik" uniqKey="Wiklund F" first="Fredik" last="Wiklund">Fredik Wiklund</name>
</country>
</tree>
</affiliations>
</record>

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Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk

Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk

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